The IQAC seminars start again in 2020 next wednesday 15th January

We are glad to announce a IQAC seminar that we will have the opportunity to listen to Dr. Maria Macias (IRB Barcelona - Institute for Research in BioMedicine of Barcelona)

Speaker: Dr. Maria Macias (Group Leader of Structural Characterization of Macromolecular Assemblies at Institute for Research in BioMedicine of Barcelona)
Title: Structural basis for genome-wide recognition of DNA clusters by SMAD transcription factors
Date: 15th January 2020 12:00
Venue: Sala d'Actes room CID-CSIC. C. Jordi Girona 18-26, 08034 Barcelona

Seminars are open to anyone. Punctuality is much appreciated since the seminar start at 12:00 sharp.



TGFβ- and BMP-activated R-Smads were believed to have different preferences with respect to the recognition of DNA motifs, and to respond to specific activation inputs. However, recent results indicate that several types of R-Smads can be activated by similar receptors and that all Smads might recognize various DNA motifs. These results pose new questions as to why different types of R-Smads have been conserved for more than 500 million years if they have a redundant function. They also raise questions as to how different Smad complexes recognize specific clusters of DNA motifs genome-wide.Here, using structural biology approaches, we elucidate some of the rules that help define the composition of Smad complexes and propose how these complexes could influence the recognition of specific cis regulatory elements genome-wide.


Martes, 14 de Enero de 2020